| [1] | 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2020概要[J]. 中国循环杂志, 2021, 36(6): 521−545. The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on cardiovascular health and diseases burden in China: an updated summary of 2020 [J]. Chinese Circulation Journal, 2021, 36(6): 521−545. DOI: 10.3969/j.issn.1000-3614.2021.06.001. The Writing Committee of the Report on Cardiovascular Health and Diseases in China. Report on cardiovascular health and diseases burden in China: an updated summary of 2020 [J]. Chinese Circulation Journal, 2021, 36(6): 521−545. DOI: 10.3969/j.issn.1000-3614.2021.06.001. |
| [2] | GYÖNGYÖSI M, WINKLER J, RAMOS I, et al. Myocardial fibrosis: biomedical research from bench to bedside [J]. European Journal of Heart Failure, 2017, 19(2): 177−191. DOI: 10.1002/ejhf.696. |
| [3] | MBOKOU FOUKMENIOK S, ILBOUDO O, KARANGA Y, et al. Direct and simultaneous quantification of rutin and quercetin in natural fruits base on purified arabic gum modified carbon paste electrode[J]. SN Applied Sciences, 2019, 1(5): 385. DOI: 10.1007/s42452-019-0413-8. |
| [4] | 陆敏佳, 蒋玉蓉, 陈国林, 等. 藜麦叶片黄酮类物质的提取及基因型差异[J]. 浙江农林大学学报, 2014, 31(4): 534−540. LU Minjia, JIANG Yurong, CHEN Guolin, et al. Flavonoid extraction and flavonoid content with genotypic variation from Chenopodium quinoa leaves [J]. Journal of Zhejiang A&F University, 2014, 31(4): 534−540. DOI: 10.11833/j.issn.2095-0756.2014.04.007. LU Minjia, JIANG Yurong, CHEN Guolin, et al. Flavonoid extraction and flavonoid content with genotypic variation from Chenopodium quinoa leaves [J]. Journal of Zhejiang A&F University, 2014, 31(4): 534−540. DOI: 10.11833/j.issn.2095-0756.2014.04.007. |
| [5] | 李瑶晨, 范紫佩, 杨静, 等. 野生蔬菜功能性成分及其生物活性研究进展[J]. 浙江农林大学学报, 2022, 39(4): 913−922. LI Yaochen, FAN Zipei, YANG Jing, et al. Research progress on functional components and biological activities of wild edible vegetables [J]. Journal of Zhejiang A&F University, 2022, 39(4): 913−922. DOI: 10.11833/j.issn.2095-0756.20210550. LI Yaochen, FAN Zipei, YANG Jing, et al. Research progress on functional components and biological activities of wild edible vegetables [J]. Journal of Zhejiang A&F University, 2022, 39(4): 913−922. DOI: 10.11833/j.issn.2095-0756.20210550. |
| [6] | WU Liang, LI Luqian, WANG Xue, et al. The inhibition of rutin on Src kinase blocks high glucose-induced EGFR/ERK transactivation in diabetic nephropathy by integrative approach of network pharmacology and experimental verification[J]. Phytomedicine, 2024, 135: 156220. DOI: 10.1016/j.phymed.2024.156220. |
| [7] | WANG Lei, ZHAO Jiali, MAO Yuanbin, et al. Tartary buckwheat rutin: accumulation, metabolic pathways, regulation mechanisms, and biofortification strategies[J]. Plant Physiology and Biochemistry, 2024, 208: 108503. DOI: 10.1016/j.plaphy.2024.108503. |
| [8] | 王斌, 赵明, 陈志勇, 等. 芦丁对单侧输尿管梗阻大鼠肾间质纤维化的作用研究[J]. 时珍国医国药, 2018, 29(8): 1796−1800. WANG Bin, ZHAO Ming, CHEN Zhiyong, et al. Effect of rutin on tubulointerstitial fibrosis in unilateral ureteral obstruction rats [J]. Lishizhen Medicine and Materia Medica Research, 2018, 29(8): 1796−1800. DOI: 10.3969/j.issn.1008-0805.2018.08.002. WANG Bin, ZHAO Ming, CHEN Zhiyong, et al. Effect of rutin on tubulointerstitial fibrosis in unilateral ureteral obstruction rats [J]. Lishizhen Medicine and Materia Medica Research, 2018, 29(8): 1796−1800. DOI: 10.3969/j.issn.1008-0805.2018.08.002. |
| [9] | 储金秀, 李光民, 韩淑英, 等. 荞麦花叶中芦丁对血管紧张素Ⅱ诱导的新生大鼠心肌细胞肥大的体外抑制作用[J]. 华西药学杂志, 2010, 25(4): 428−430. CHU Jinxiu, LI Guangmin, HAN Shuying, et al. In vitro inhibitory effects of rutin from buckwheat flowers and leaves on angiotensin Ⅱ induced cardiomyocytes hypertrophy of neonatal rat[J]. West China Journal of Pharmaceutical Sciences, 2010, 25(4): 428−430. DOI: 10.13375/j.cnki.wcjps.2010.04.013. CHU Jinxiu, LI Guangmin, HAN Shuying, et al. In vitro inhibitory effects of rutin from buckwheat flowers and leaves on angiotensin Ⅱ induced cardiomyocytes hypertrophy of neonatal rat[J]. West China Journal of Pharmaceutical Sciences, 2010, 25(4): 428−430. DOI: 10.13375/j.cnki.wcjps.2010.04.013. |
| [10] | EBERHARDT J, SANTOS-MARTINS D, TILLACK A F, et al. AutoDock vina 1.2.0: new docking methods, expanded force field, and Python bindings [J]. Journal of Chemical Information and Modeling, 2021, 61(8): 3891−3898. DOI: 10.1021/acs.jcim.1c00203. |
| [11] | 牛丕莲, 范永鑫, 路富瑞, 等. 甘草提取物对TGF-β1诱导心肌成纤维细胞纤维化的影响[J]. 中国临床药理学与治疗学, 2022, 27(2): 129−135. NIU Pilian, FAN Yongxin, LU Furui, et al. Effects of liquorice extract on cardiac fibroblasts fibrosis induced by TGF-β1 [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(2): 129−135. DOI: 10.12092/j.issn.1009-2501.2022.02.002. NIU Pilian, FAN Yongxin, LU Furui, et al. Effects of liquorice extract on cardiac fibroblasts fibrosis induced by TGF-β1 [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(2): 129−135. DOI: 10.12092/j.issn.1009-2501.2022.02.002. |
| [12] | CLELAND J G F, PELLICORI P, GONZÁLEZ A. A novel treatment for heart failure targets myocardial fibrosis [J]. Nature Medicine, 2021, 27(8): 1343−1344. DOI: 10.1038/s41591-021-01457-9. |
| [13] | WILSON A J, GILL E K, ABUDALO R A, et al. Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting [J]. Heart, 2018, 104(4): 293−299. DOI: 10.1136/heartjnl-2017-311448. |
| [14] | YI Tongtong, ZHANG Wei, HUA Ying, et al. Rutin alleviates lupus nephritis by inhibiting T cell oxidative stress through PPARγ[J]. Chemico-Biological Interactions, 2024, 394: 110972. DOI: 10.1016/j.cbi.2024.110972. |
| [15] | 李阳, 黄彬龙, 林琳, 等. 芦丁对心肌纤维化大鼠ColⅠ、ColⅢ、TGF-β1的调控作用[J]. 热带医学杂志, 2017, 17(2): 174−176. LI Yang, HUANG Binlong, LIN Lin, et al. Effects of rutin on the regulation of ColⅠ, Col Ⅲ, TGF-β1 expression in myocardial fibrosis rats [J]. Journal of Tropical Medicine, 2017, 17(2): 174−176. DOI: 10.3969/j.issn.1672-3619.2017.02.009. LI Yang, HUANG Binlong, LIN Lin, et al. Effects of rutin on the regulation of ColⅠ, Col Ⅲ, TGF-β1 expression in myocardial fibrosis rats [J]. Journal of Tropical Medicine, 2017, 17(2): 174−176. DOI: 10.3969/j.issn.1672-3619.2017.02.009. |
| [16] | 曹皓轩, 孙竹梅, 勾向博, 等. 芦丁对1型糖尿病小鼠心肌酶及心肌组织形态学影响[J]. 四川大学学报(医学版), 2018, 49(4): 570−574. CAO Haoxuan, SUN Zhumei, GOU Xiangbo, et al. Effects of rutin on myocardial enzyme and cardiac morphology in diabetic mice [J]. Journal of Sichuan University (Medical Sciences), 2018, 49(4): 570−574. DOI: 10.13464/j.scuxbyxb.2018.04.013. CAO Haoxuan, SUN Zhumei, GOU Xiangbo, et al. Effects of rutin on myocardial enzyme and cardiac morphology in diabetic mice [J]. Journal of Sichuan University (Medical Sciences), 2018, 49(4): 570−574. |
| [17] | ZHU Mingyang, HE Qingmin, WANG Yanan, et al. Exploring the mechanism of Aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments[J]. Frontiers in Pharmacology, 2023, 14: 1238841. DOI: 10.3389/fphar.2023.1238841. |
| [18] | 石晓冬, 卢登勇, 吴慧敏, 等. 基于网络药理学探讨黄芪-丹参干预肾纤维化的作用机制[J]. 西部中医药, 2025, 38(4): 53−58. SHI Xiaodong, LU Dengyong, WU Huimin, et al. Network pharmacology-based discussion on the mechanism of intervention of renal fibrosis with Huangqi-Danshen couplet medicines [J]. Western Journal of Traditional Chinese Medicine, 2025, 38(4): 53−58. DOI: 10.12174/j.issn.2096-9600.2025.04.11. SHI Xiaodong, LU Dengyong, WU Huimin, et al. Network pharmacology-based discussion on the mechanism of intervention of renal fibrosis with Huangqi-Danshen couplet medicines [J]. Western Journal of Traditional Chinese Medicine, 2025, 38(4): 53−58. DOI: 10.12174/j.issn.2096-9600.2025.04.11. |
| [19] | 杨开燕, 李淑玲, 魏惠平, 等. 当归-红芪药对抗心肌纤维化作用的机制分: 基于生物信息学技术[J/OL]. 中国全科医学, 2024-11-08[2025-06-09]. http://kns.cnki.net/kcms/detail/13.1222.R.20241108.0909.002.html. YANG Kaiyan, LI Shuling, WEI Huiping, et al. Exploring the effective components and mechanism of action of Danggui-Hongqi in the treatment of myocardial fibrosis based on bioinformatics technology[J/OL]. Chinese General Practice, 2024-11-08[2025-06-09]. http://kns.cnki.net/kcms/detail/13.1222.R.20241108.0909.002.html. YANG Kaiyan, LI Shuling, WEI Huiping, et al. Exploring the effective components and mechanism of action of Danggui-Hongqi in the treatment of myocardial fibrosis based on bioinformatics technology[J/OL]. Chinese General Practice, 2024-11-08[2025-06-09]. http://kns.cnki.net/kcms/detail/13.1222.R.20241108.0909.002.html. |
| [20] | WANG Jiahong, ZHAO Lan, PAN Xin, et al. Hypoxia-stimulated cardiac fibroblast production of IL-6 promotes myocardial fibrosis via the TGF-β1 signaling pathway[J]. Laboratory Investigation; a Journal of Technical Methods and Pathology, 2016, 96(9): 1035. DOI: 10.1038/labinvest.2016.84. |
| [21] | 曾清清, 高忠兰, 陈务贤, 等. 高盐诱导高血压大鼠心肌间质重构及SHIP-1和IL-6的表达研究[J]. 广西医科大学学报, 2023, 40(1): 54−58. ZENG Qingqing, GAO Zhonglan, CHEN Wuxian, et al. Myocardial interstitial remodeling and expressions of SHIP-1 and IL-6 in high-salt-induced hypertensive rats [J]. Journal of Guangxi Medical University, 2023, 40(1): 54−58. DOI: 10.16190/j.cnki.45-1211/r.2023.01.009. ZENG Qingqing, GAO Zhonglan, CHEN Wuxian, et al. Myocardial interstitial remodeling and expressions of SHIP-1 and IL-6 in high-salt-induced hypertensive rats [J]. Journal of Guangxi Medical University, 2023, 40(1): 54−58. |
| [22] | 王文婷, 徐寒梅, 李梦玮, 等. 基质金属蛋白酶及整合素在肺纤维化中的作用[J]. 药物生物技术, 2023, 30(2): 180−185. WANG Wenting, XU Hanmei, LI Mengwei, et al. Important roles of matrix metalloproteinases and integrins in pulmonary fibrosis [J]. Pharmaceutical Biotechnology, 2023, 30(2): 180−185. DOI: 10.19526/j.cnki.1005-8915.20230214. WANG Wenting, XU Hanmei, LI Mengwei, et al. Important roles of matrix metalloproteinases and integrins in pulmonary fibrosis [J]. Pharmaceutical Biotechnology, 2023, 30(2): 180−185. DOI: 10.19526/j.cnki.1005-8915.20230214. |
| [23] | CHANDA D, OTOUPALOVA E, SMITH S R, et al. Developmental pathways in the pathogenesis of lung fibrosis [J]. Molecular Aspects of Medicine, 2019, 65: 56−69. DOI: 10.1016/j.mam.2018.08.004. |
| [24] | GONZÁLEZ A, LÓPEZ B, RAVASSA S, et al. The complex dynamics of myocardial interstitial fibrosis in heart failure. Focus on collagen cross-linking [J]. Biochimica et Biophysica Acta. Molecular Cell Research, 2019, 1866(9): 1421−1432. DOI: 10.1016/j.bbamcr.2019.06.001. |
| [25] | ZHANG Zeyu, YANG Zhihua, WANG Shuai, et al. Targeting MAPK-ERK/JNK pathway: a potential intervention mechanism of myocardial fibrosis in heart failure[J]. Biomedecine & Pharmacotherapie, 2024, 173: 116413. DOI: 10.1016/j.biopha.2024.116413. |
| [26] | VIEDT C, SOTO U, KRIEGER-BRAUER H I, et al. Differential activation of mitogen-activated protein kinases in smooth muscle cells by angiotensin Ⅱ: involvement of p22phox and reactive oxygen species [J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2000, 20(4): 940−948. DOI: 10.1161/01.ATV.20.4.940. |
| [27] | 张金丽, 苏飞, 张焕婷, 等. 化浊解毒调肝方对乙型肝炎大鼠肝纤维化、免疫功能及Ras/ERK信号通路的影响[J]. 中西医结合肝病杂志, 2024, 34(5): 409−413. ZHANG Jinli, SU Fei, ZHANG Huanting, et al. Study of Huozhujiedu Tiaogan prescription on liver fibrosis, immune function and Ras/ERK signaling pathway in rats with hepatitis B [J]. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases, 2024, 34(5): 409−413. DOI: 10.3969/j.issn.1005-0264.2024.005.007. ZHANG Jinli, SU Fei, ZHANG Huanting, et al. Study of Huozhujiedu Tiaogan prescription on liver fibrosis, immune function and Ras/ERK signaling pathway in rats with hepatitis B [J]. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases, 2024, 34(5): 409−413. DOI: 10.3969/j.issn.1005-0264.2024.005.007. |
| [28] | WANG Junyan, DENG Bo, LIU Qing, et al. Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload[J]. Cell Death & Disease, 2020, 11(7): 574. DOI: 10.1038/s41419-020-02777-3. |
| [29] | 王文化. 地胆草活性成分去氧地胆草素通过抑制p38 MAPK信号通路改善力竭运动诱导的心肌损伤[J]. 分子植物育种, 2025, 23(16): 5530−5537. WANG Wenhua. Deoxyelephantopin, the active ingredient of Elephantopus scaber L. , improves myocardium injury induced by exhaustive exercise by inhibiting p38 MAPK signaling pathway[J]. Molecular Plant Breeding, 2025, 23(16): 5530−5537. DOI: 10.13271/j.mpb.023.005530. WANG Wenhua. Deoxyelephantopin, the active ingredient of Elephantopus scaber L. , improves myocardium injury induced by exhaustive exercise by inhibiting p38 MAPK signaling pathway[J]. Molecular Plant Breeding, 2025, 23(16): 5530−5537. DOI: 10.13271/j.mpb.023.005530. |
| [30] | SUN Haijuan, BAI Jingjing, SUN Yuting, et al. Oxymatrine attenuated isoproterenol-induced heart failure via the TLR4/NF-κB and MAPK pathways in vivo and in vitro[J]. European Journal of Pharmacology, 2023, 941: 175500. DOI: 10.1016/j.ejphar.2023.175500. |
| [31] | 朱凯, 秦小鹏. 肉桂提取物与抗阻运动对肥胖大鼠心肌线粒体功能的保护作用[J]. 分子植物育种, 2024, 22(21): 7206−7214. ZHU Kai, QIN Xiaopeng. Protective effects of cinnamon extract and resistance exercise on myocardial mitochondrial function in obese rats [J]. Molecular Plant Breeding, 2024, 22(21): 7206−7214. DOI: 10.13271/j.mpb.022.007206. ZHU Kai, QIN Xiaopeng. Protective effects of cinnamon extract and resistance exercise on myocardial mitochondrial function in obese rats [J]. Molecular Plant Breeding, 2024, 22(21): 7206−7214. DOI: 10.13271/j.mpb.022.007206. |