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摘要: 胆固醇7-羟化酶(cholesterol 7-hydroxylase,CYP7A1)是胆汁酸经典合成途径中的限速酶,对维持机体胆固醇代谢平衡起关键作用。目前已知CYP7A1基因的表达受包括该基因自身的多态性在内的多种因子调控。CYP7A1代谢途径作为脂类代谢通路的重要一部分,其活性发生改变后可能会引起与脂类代谢紊乱有关的胆结石、胆囊癌和心血管疾病等。就有关CYP7A1基因的最新研究进展进行了较系统的综述。图1参53
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关键词:
- 动物学 /
- 胆固醇7α-羟化酶基因 /
- 基因表达调控 /
- 胆汁酸代谢 /
- 综述
Abstract: As a key rate-limiting enzyme in classical biosynthesis pathway of bile acids,cholesterol 7-hy-droxylase(CYP7A1)plays a vital role in keeping homeostasis of cholesterol metabolism. The expression of CYP7A1 is regulated by many factors including its single nucleotide polymorphisms. CYP7A1 metabolism is a part of lipids metabolic pathway, the change of its activity may lead to disease due to lipids metabolic disorder,such as gall-stone,gallbladder cancer, angiocardiopathy and so on. This paper reviewed and summarized the related research progresses on CYP7A1 gene in recent decades. [Ch,1 fig. 53 ref.]-
Key words:
- zoology /
- cholesterol 7α-hydroxylase gene /
- gene expression regulation /
- bile acids metabolic /
- review
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链接本文:
https://zlxb.zafu.edu.cn/article/doi/10.11833/j.issn.2095-0756.2013.05.019
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