Research progresses on cholesterol 7α-hydroxylase gene （CYP7A1）

DU Xue; LI Jinjun; LU Lizhi; ZHAO Ayong

doi:10.11833/j.issn.2095-0756.2013.05.019

Volume 30 Issue 5

Sep. 2013

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DU Xue, LI Jinjun, LU Lizhi, ZHAO Ayong. Research progresses on cholesterol 7α-hydroxylase gene （CYP7A1）[J]. Journal of Zhejiang A&F University, 2013, 30(5): 755-760. doi: 10.11833/j.issn.2095-0756.2013.05.019

Citation:

DU Xue, LI Jinjun, LU Lizhi, ZHAO Ayong. Research progresses on cholesterol 7α-hydroxylase gene （CYP7A1）[J]. Journal of Zhejiang A&F University, 2013, 30(5): 755-760. doi: 10.11833/j.issn.2095-0756.2013.05.019

Research progresses on cholesterol 7α-hydroxylase gene （CYP7A1）

doi: 10.11833/j.issn.2095-0756.2013.05.019

DU Xue^1,2,
LI Jinjun²,
LU Lizhi²,
ZHAO Ayong^{1
,
,}

1.
School of Forestry and Biotechnology，Zhejiang A & F University，Lin’an 311300，Zhejiang，China;
2.
Institute of Animal Husbandry and Veterinary Science，Zhejiang Academy of Agricultural Sciences，Hangzhou 310021，Zhejiang，China

More Information

Corresponding author: ZHAO Ayong
Received Date: 2012-10-30
Rev Recd Date: 2013-02-11
Publish Date: 2013-10-20

Abstract

As a key rate-limiting enzyme in classical biosynthesis pathway of bile acids，cholesterol 7-hy-droxylase（CYP7A1）plays a vital role in keeping homeostasis of cholesterol metabolism. The expression of CYP7A1 is regulated by many factors including its single nucleotide polymorphisms. CYP7A1 metabolism is a part of lipids metabolic pathway, the change of its activity may lead to disease due to lipids metabolic disorder，such as gall-stone，gallbladder cancer, angiocardiopathy and so on. This paper reviewed and summarized the related research progresses on CYP7A1 gene in recent decades. ［Ch，1 fig. 53 ref.］
- zoology,
- cholesterol 7α-hydroxylase gene,
- gene expression regulation,
- bile acids metabolic,
- review

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Research progresses on cholesterol 7α-hydroxylase gene （CYP7A1）

1. School of Forestry and Biotechnology，Zhejiang A & F University，Lin’an 311300，Zhejiang，China;

2. Institute of Animal Husbandry and Veterinary Science，Zhejiang Academy of Agricultural Sciences，Hangzhou 310021，Zhejiang，China

Corresponding author: ZHAO Ayong

Received Date: 2012-10-30

Rev Recd Date: 2013-02-11

Publish Date: 2013-10-20

Key words:

Abstract: As a key rate-limiting enzyme in classical biosynthesis pathway of bile acids，cholesterol 7-hy-droxylase（CYP7A1）plays a vital role in keeping homeostasis of cholesterol metabolism. The expression of CYP7A1 is regulated by many factors including its single nucleotide polymorphisms. CYP7A1 metabolism is a part of lipids metabolic pathway, the change of its activity may lead to disease due to lipids metabolic disorder，such as gall-stone，gallbladder cancer, angiocardiopathy and so on. This paper reviewed and summarized the related research progresses on CYP7A1 gene in recent decades. ［Ch，1 fig. 53 ref.］

Research progresses on cholesterol 7α-hydroxylase gene （CYP7A1）

doi: 10.11833/j.issn.2095-0756.2013.05.019

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

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