Volume 30 Issue 5
Sep.  2013
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DU Xue, LI Jinjun, LU Lizhi, ZHAO Ayong. Research progresses on cholesterol 7α-hydroxylase gene (CYP7A1)[J]. Journal of Zhejiang A&F University, 2013, 30(5): 755-760. doi: 10.11833/j.issn.2095-0756.2013.05.019
Citation: DU Xue, LI Jinjun, LU Lizhi, ZHAO Ayong. Research progresses on cholesterol 7α-hydroxylase gene (CYP7A1)[J]. Journal of Zhejiang A&F University, 2013, 30(5): 755-760. doi: 10.11833/j.issn.2095-0756.2013.05.019

Research progresses on cholesterol 7α-hydroxylase gene (CYP7A1)

doi: 10.11833/j.issn.2095-0756.2013.05.019
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  • Corresponding author: ZHAO Ayong
  • Received Date: 2012-10-30
  • Rev Recd Date: 2013-02-11
  • Publish Date: 2013-10-20
通讯作者: 陈斌, bchen63@163.com
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Research progresses on cholesterol 7α-hydroxylase gene (CYP7A1)

doi: 10.11833/j.issn.2095-0756.2013.05.019
    Corresponding author: ZHAO Ayong

Abstract: As a key rate-limiting enzyme in classical biosynthesis pathway of bile acids,cholesterol 7-hy-droxylase(CYP7A1)plays a vital role in keeping homeostasis of cholesterol metabolism. The expression of CYP7A1 is regulated by many factors including its single nucleotide polymorphisms. CYP7A1 metabolism is a part of lipids metabolic pathway, the change of its activity may lead to disease due to lipids metabolic disorder,such as gall-stone,gallbladder cancer, angiocardiopathy and so on. This paper reviewed and summarized the related research progresses on CYP7A1 gene in recent decades. [Ch,1 fig. 53 ref.]

DU Xue, LI Jinjun, LU Lizhi, ZHAO Ayong. Research progresses on cholesterol 7α-hydroxylase gene (CYP7A1)[J]. Journal of Zhejiang A&F University, 2013, 30(5): 755-760. doi: 10.11833/j.issn.2095-0756.2013.05.019
Citation: DU Xue, LI Jinjun, LU Lizhi, ZHAO Ayong. Research progresses on cholesterol 7α-hydroxylase gene (CYP7A1)[J]. Journal of Zhejiang A&F University, 2013, 30(5): 755-760. doi: 10.11833/j.issn.2095-0756.2013.05.019

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