Camptothecin：a biosynthetic pathway with associated enzymes and genes

WANG Lei; WU Jia-sheng; LIAO Liang

Volume 25 Issue 6

Dec. 2008

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WANG Lei, WU Jia-sheng, LIAO Liang. Camptothecin：a biosynthetic pathway with associated enzymes and genes[J]. Journal of Zhejiang A&F University, 2008, 25(6): 791-797.

Citation:

WANG Lei, WU Jia-sheng, LIAO Liang. Camptothecin：a biosynthetic pathway with associated enzymes and genes[J]. Journal of Zhejiang A&F University, 2008, 25(6): 791-797.

Camptothecin：a biosynthetic pathway with associated enzymes and genes

1.
School of Forestry and Biotechnology，Zhejiang Forestry College，Lin’an 311300，Zhejiang，China;
2.
Forest Enterprise of Yueqing City，Yueqing 325600， Zhejiang，China

More Information

Corresponding author: WU Jia-sheng
Publish Date: 2008-12-20

Abstract

Camptothecin is a monoterpene indole alkaloid found in Camptotheca acuminata，which is native to China. After the discovery taxol as an anti-cancer agent，C. acuminata became a favored plant-based anti-cancer medicine with exceptional market prospects. Due to a lack of Camptotheca trees and the high demand of camptothecin，metabolic engineering has been employed to improve camptothecin yield. Thus，the biosynthetic pathway of camptothecin is being studied. Based on the literature，the camptothecin biosynthetic pathway can be divided into upper and lower pathways with strictosidine as the dividing line. In this paper the biosyntheses of many intermediate products in the pathway，including related enzymes and genes，are discussed in detail. Possible methods for regulating camptothecin biosynthesis along with key issues for future studies are also mentioned. ［Ch，3 fig. 1 tab. 29 ref.］
- botany,
- camptothecin,
- biosynthetic pathway,
- key enzyme

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Camptothecin：a biosynthetic pathway with associated enzymes and genes

1. School of Forestry and Biotechnology，Zhejiang Forestry College，Lin’an 311300，Zhejiang，China;

2. Forest Enterprise of Yueqing City，Yueqing 325600， Zhejiang，China

Corresponding author: WU Jia-sheng

Publish Date: 2008-12-20

Key words:

Abstract: Camptothecin is a monoterpene indole alkaloid found in Camptotheca acuminata，which is native to China. After the discovery taxol as an anti-cancer agent，C. acuminata became a favored plant-based anti-cancer medicine with exceptional market prospects. Due to a lack of Camptotheca trees and the high demand of camptothecin，metabolic engineering has been employed to improve camptothecin yield. Thus，the biosynthetic pathway of camptothecin is being studied. Based on the literature，the camptothecin biosynthetic pathway can be divided into upper and lower pathways with strictosidine as the dividing line. In this paper the biosyntheses of many intermediate products in the pathway，including related enzymes and genes，are discussed in detail. Possible methods for regulating camptothecin biosynthesis along with key issues for future studies are also mentioned. ［Ch，3 fig. 1 tab. 29 ref.］

Camptothecin：a biosynthetic pathway with associated enzymes and genes

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Related

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