Volume 26 Issue 1
Feb.  2009
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GUAN Yu, ZHANG Xiang-yun, XU Qun-fang, WU Zhi-song, GU Guang-tong, NIE Wen. Hardy-Weinberg equilibrium testing and estimating of allele frequency[J]. Journal of Zhejiang A&F University, 2009, 26(1): 122-126.
Citation: GUAN Yu, ZHANG Xiang-yun, XU Qun-fang, WU Zhi-song, GU Guang-tong, NIE Wen. Hardy-Weinberg equilibrium testing and estimating of allele frequency[J]. Journal of Zhejiang A&F University, 2009, 26(1): 122-126.

Hardy-Weinberg equilibrium testing and estimating of allele frequency

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  • Corresponding author: GUAN Yu
  • Received Date: 2008-06-23
  • Rev Recd Date: 2008-09-26
  • Publish Date: 2009-02-20
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Hardy-Weinberg equilibrium testing and estimating of allele frequency

    Corresponding author: GUAN Yu

Abstract: As the most important principle in population genetics,Hardy-Weinberg equilibrium (HWE) is a rule to check whether observed genotypic frequencies and allele frequencies between parents and their offspring are in equilibrium in a population. During HWE testing,frequencies of those alleles must be estimated. When there were dominant and recessive genotypes,we used Newton alternate algorithm to get maximum likelihood estimate(MLE) of allele frequencies. The research findings indicated that Newton alternate algorithm had a faster convergence than method of maximum likelihood. An approximate formula about the least Pearson χ2 statistic estimate and MLE was discussed. Newton alternate algorithm on MLE and the least Pearson χ2 statistic estimate were recommended. [Ch,10 ref.]

GUAN Yu, ZHANG Xiang-yun, XU Qun-fang, WU Zhi-song, GU Guang-tong, NIE Wen. Hardy-Weinberg equilibrium testing and estimating of allele frequency[J]. Journal of Zhejiang A&F University, 2009, 26(1): 122-126.
Citation: GUAN Yu, ZHANG Xiang-yun, XU Qun-fang, WU Zhi-song, GU Guang-tong, NIE Wen. Hardy-Weinberg equilibrium testing and estimating of allele frequency[J]. Journal of Zhejiang A&F University, 2009, 26(1): 122-126.

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